{"id":306,"date":"2020-03-03T15:24:15","date_gmt":"2020-03-03T23:24:15","guid":{"rendered":"https:\/\/duckcafe.com\/rootvoid\/?p=306"},"modified":"2020-03-03T15:24:15","modified_gmt":"2020-03-03T23:24:15","slug":"the-neuroinvasive-potential-of-sars%e2%80%90cov2-may-be-at-least-partially-responsible-for-the-respiratory-failure-of-covid%e2%80%9019-patients","status":"publish","type":"post","link":"https:\/\/duckcafe.com\/rootvoid\/2020\/03\/03\/the-neuroinvasive-potential-of-sars%e2%80%90cov2-may-be-at-least-partially-responsible-for-the-respiratory-failure-of-covid%e2%80%9019-patients\/","title":{"rendered":"The neuroinvasive potential of SARS\u2010CoV2 may be at least partially responsible for the respiratory failure of COVID\u201019 patients"},"content":{"rendered":"<h2><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/jmv.25728\" target=\"_blank\" rel=\"noopener noreferrer\">The neuroinvasive potential of SARS\u2010CoV2 may be at least partially responsible for the respiratory failure of COVID\u201019 patients<\/a><\/h2>\n<p>Yan\u2010Chao Li, Wan\u2010Zhu Bai, Tsutomu Hashikawa<br \/>\nFirst published: 27 February 2020<br \/>\nhttps:\/\/doi.org\/10.1002\/jmv.25728<\/p>\n<h3>Abstract<\/h3>\n<p>Following the severe acute respiratory syndrome coronavirus (SARS\u2010CoV) and Middle East respiratory syndrome coronavirus (MERS\u2010CoV), another highly pathogenic coronavirus named SARS\u2010CoV\u20102 (previously known as 2019\u2010nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS\u2010CoV, and causes acute, highly lethal pneumonia (COVID\u201019) with clinical symptoms similar to those reported for SARS\u2010CoV and MERS\u2010CoV.<\/p>\n<h4>The most characteristic symptom of COVID\u201019 patients is respiratory distress, and most of the patients admitted to the intensive care could not breathe spontaneously.<\/h4>\n<p>Additionally, some COVID\u201019 patients also showed neurologic signs such as headache, nausea and vomiting. Increasing evidence shows that coronavriruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases.<\/p>\n<h3>The infection of SARS\u2010CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected.<\/h3>\n<p>Furthermore, some coronaviruses have been demonstrated able to spread via a synapse\u2010connected route to the medullary cardiorespiratory center from the mechano\u2010 and chemoreceptors in the lung and lower respiratory airways. In light of the high similarity between SARS\u2010CoV and SARS\u2010CoV2, it is quite likely that the potential invasion of SARS\u2010CoV2 is partially responsible for the acute respiratory failure of COVID\u201019 patients. Awareness of this will have important guiding significance for the prevention and treatment of the SARS\u2010CoV\u20102\u2010induced respiratory failure. (229 words)<\/p>\n<h3>Full article <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/jmv.25728\" target=\"_blank\" rel=\"noopener noreferrer\">HERE<\/a>.<\/h3>\n","protected":false},"excerpt":{"rendered":"<p>The neuroinvasive potential of SARS\u2010CoV2 may be at least partially responsible for the respiratory failure of COVID\u201019 patients Yan\u2010Chao Li, Wan\u2010Zhu Bai, Tsutomu Hashikawa First published: 27 February 2020 https:\/\/doi.org\/10.1002\/jmv.25728 Abstract Following the severe acute respiratory syndrome coronavirus (SARS\u2010CoV) and Middle East respiratory syndrome coronavirus (MERS\u2010CoV), another highly pathogenic coronavirus named SARS\u2010CoV\u20102 (previously known as [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[20,18,15],"_links":{"self":[{"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/posts\/306"}],"collection":[{"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/comments?post=306"}],"version-history":[{"count":1,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/posts\/306\/revisions"}],"predecessor-version":[{"id":307,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/posts\/306\/revisions\/307"}],"wp:attachment":[{"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/media?parent=306"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/categories?post=306"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/duckcafe.com\/rootvoid\/wp-json\/wp\/v2\/tags?post=306"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}